Mechanistic Machine Learning and Digital Twins for Computational Science, Engineering & Technology

An IACM Conference

September 26-29, 2021 - Hyatt Regency Mission Bay, San Diego, CA


See photos from the hybrid 2021 MMLDT-CSET conference!

Important Updates

  • The Conference Program-at-a-glance and other major events are availble on the Program page.

  • In-person participants should review the COVID-19 guidelines.

  • Pre-recorded video presentation submissions are due by September 10, 2359 PT. More information can be found on the Submissions page.


Machine Learning (ML) and Digital Twins (DT) are at the heart of today’s different industries, ranging from advanced manufacturing to biomedical systems to resilient ecosystems, civil infrastructures, smart cities, and healthcare. They have become indispensable for solving complex problems in science, engineering, and technology development. The purpose of the MMLDT-CSET 2021 conference is to facilitate the transition of ML and DT from fundamental research to mainstream fields and technologies through advanced data science, mechanistic methods, and computational technologies. This 3-day conference features technical tracks of emerging ML-DT fields and applications, special public lectures, short courses, and demonstrations. The conference will be held in a hybrid format, featuring both on-site and virtual sessions.


The goal of this MMLDT-CSET Conference is to bring together the diverse communities that are interested in learning, developing, and applying mechanistic machine learning and digital twins via computational science and engineering tools to a broad range of engineering and scientific problems, and to promote collaborations between engineers, data and computer scientists, and mathematicians from federal agencies, academia, and industry in this field.

Conference Topics

  • Track 1: Multiscale Materials and Engineered Systems

  • Track 2: Scientific and Engineering Digital Twins

  • Track 3: Biomedical Systems, Medical Devices, and Mechanistic ML Enhanced Diagnostics

  • Track 4: Reduced-order Modeling for Fluids, Solids, and Structures

  • Track 5: Geosystem, Geostatistics, and Petroleum Engineering

  • Track 6: Infrastructure and Cyberinfrastructure Systems

  • Track 7: Technology Transfer for Innovative Scientific and Engineering Applications

  • Track 8: Panel for Education, Outreach, and Funding Opportunities

Important Dates

  • September 16, 2020December 31, 2020: Mini-symposium Proposal submission

  • February 1 May 15, 2021: Abstract Submission

  • May 17 to June 30, 2021: Early Registration

  • July 1 to August 5, 2021: Regular Registration

  • August 6 to September 29, 2021: Late Registration

  • September 26 - 29, 2021: Conference

UC San Diego, Department of Structural Engineering, 9500 Gilman Dr MC 0085, La Jolla, CA 92093-0085
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